CloudFront cache, can "request.uri" be part of the cache key?

I have read the cache key documentation on cloudfront:

https://aws.amazon.com/blogs/networking-and-content-delivery/amazon-cloudfront-announces-cache-and-origin-request-policies/

I have a lambda@edge function that gets triggered by Viewer Request. There I set request.uri to values I need to fetch proper files from S3.

From the documentation I don’t see anything about request.uri being part of what the cache key considers.

Is there a way to make request.uri affect the cache key?

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